Svanova Biotech

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	NOVEL SOLUTIONS FOR THE SUSTAINABLE CONTROL OF NEMATODES IN RUMINANTS PARASOL 2006 - 2009 Sujets : Standards, Environmental Protection, Safety, Biotechnology, Scientific Research, Resources of the Sea, Fisheries, Evaluation, Social Aspects, Life Sciences, Agriculture, Food, Medicine, Health Type de contrat : Specific Targeted Research Project Participants : UNIVERSITEIT GENT BELGIQUE-BELGIË UNIVERSITEIT GENT Education UGENT, FACULTY OF VETERINARY MEDICINE, LABORATORY OF PARASITOLOGY Sint-Pietersnieuwstraat 25 BELGIQUE-BELGIË National Wool Growers' Association SOUTH AFRICA National Wool Growers' Association Other NWGA Training and Development Division PO Box 6055 41A Pickering Street, Newton Park 34291 SOUTH AFRICA SVANOVA BIOTECH AB SVERIGE SVANOVA BIOTECH AB Industry SVANOVA BIOTECH AB Uppsala Science Park SVERIGE Plantamedium GmbH DEUTSCHLAND Plantamedium GmbH Other Plantamedium GmbH Postfach 48231 Everswinkeler Str. 7 20 01 24 DEUTSCHLAND FRAENZ & JAEGER GMBH DEUTSCHLAND FRAENZ & JAEGER GMBH Industry FRÄNZ & JAEGER GMBH Schurzelter Strasse 27 DEUTSCHLAND UNIVERSITY OF BATH UNITED KINGDOM UNIVERSITY OF BATH Education DEPARTMENT OF BIOLOGY & BIOCHEMISTRY, UNIVERSITY OF BATH Claverton Down UNITED KINGDOM UNIVERSITY OF BRISTOL UNITED KINGDOM UNIVERSITY OF BRISTOL Education DEPARTMENT OF CLINICAL VETERINARY SCIENCE Senate House, Tyndall Avenue UNITED KINGDOM INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE FRANCE INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Research UNITÉ BIO-AGRESSEURS, SANTÉ, ENVIRONNEMENT (BASE) rue de l'Université 147 FRANCE STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER DEUTSCHLAND STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Education UNIVERSITY OF VETERINARY MEDICINE HANNOVER Buenteweg 2 DEUTSCHLAND SVERIGES LANTBRUKSUNIVERSITET SVERIGE SVERIGES LANTBRUKSUNIVERSITET Education DEPARTMENT OF BIOMEDICAL SCIENCES AND VETERINARY PUBLIC HEALTH, FACULTY OF VETERINARY MEDICINE AND ANIMAL SCIENCE, DIVISION OF PARASITOLOGY PO Box 7070 Arrheniusplan 2C SVERIGE MOREDUN RESEARCH INSTITUTE UNITED KINGDOM MOREDUN RESEARCH INSTITUTE Research MOREDUN RESEARCH INSTITUTE, PARASITOLOGY DIVISION, GENERAL PARASITOLOGY LABORATORY Pentland Science Park, Bush Loan, Penicuik UNITED KINGDOM PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES SLOVENSKA REPUBLIKA PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES Research PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES Hlinkova 3 SLOVENSKA REPUBLIKA University of Pretoria SOUTH AFRICA University of Pretoria Education Departments of Production Animal Studies and Veterinary Tropical Diseases, Faculty of Veterinary Science PO Box 0002 Lynnwood Road None SOUTH AFRICA INSTITUT AGRONOMIQUE ET VÉTÉRINAIRE HASSAN II MOROCCO INSTITUT AGRONOMIQUE ET VÉTÉRINAIRE HASSAN II Education DEPARTMENT OF PARASITOLOGY AND PARASITIC DISEASES PO Box 6202 Madinat Al Irfane MOROCCO ARISTOTELIO PANEPISTIMIO THESSALONIKIS HELLAS ARISTOTELIO PANEPISTIMIO THESSALONIKIS Education SCHOOL OF VETERINARY MEDICINE/ ARISTOTLE UNIVERSITY OF THESSALONIKI / LABORATORY OF PARASITOLOGY AND PARASITIC DISEASES Administration Building - University Campus HELLAS UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II ITALIA UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Research DEPARTMENT OF PATHOLOGY AND ANIMAL HEALTH, DIVISION OF PARASITOLOGY AND PARASITIC DISEASE Via della Veterinaria, 1 ITALIA FRAENZ & JAEGER Germany FRAENZ & JAEGER Industry FRÄNZ & JAEGER GMBH Schurzelter Strasse 27 Germany SVANOVA BIOTECH Sweden SVANOVA BIOTECH Industry SVANOVA BIOTECH AB Uppsala Science Park Sweden INNOVIS United Kingdom INNOVIS Industry INNOVIS Peithyll Centre, Capel Dewi United Kingdom Hide objective PARASOL focuses on gastro-intestinal nematode parasites of ruminants as they are the greatest threat to animal welfare and production, and since effective contributions can be made within three years. Current conventional methods for worm control involve repeated dosing of whole herds with synthetic anthelmintics but are unsustainable due to the food and environmental residues produced and promote the spread of anthelmintic resistance by failing to leave an untreated parasite refugium. Effective chemical anthelmintics remain irreplaceable for worm control and their elimination is not practical on animal welfare and economic grounds. We will replace current practice with Targeted Selective Treatments, where only animals showing clinical symptoms or reduced productivity are given drugs. Animals with low worm burdens are symptomless and do not require treatment. We will assess several innovative methods, under various farming conditions, for identifying animals that require treatment, and produce and standardise tests for anthelmintic resistance to ensure that the drugs are effective. We will produce, by the end of the project, clear guidance and protocols for sustainable, low-input, user- and consumer-friendly nematode control. In order to do this we will: (1) assess the effect of targeted selective treatments on productivity, animal welfare and the spread of anthelmintic resistance genes under a range of farming conditions; (2) determine the best methods of identifying animals and herds requiring anthelmintic intervention; (3) standardise existing in vivo and in vitro tests for detecting anthelmintic resistance and develop new tests for where current ones are inadequate; (4) optimise the efficacy and bio-availability of anthelmintics by modulating parasite P-glycoprotein detoxification systems; and (5) communicate with farmers, veterinarians and advisors, to produce and disseminate guidance to ensure good uptake and implementation of the protocols produced. Source : cordis   NOVEL SOLUTIONS FOR THE SUSTAINABLE CONTROL OF NEMATODES IN RUMINANTS PARASOL 2006 - 2009 Sujets : Standards, Environmental Protection, Safety, Biotechnology, Scientific Research, Resources of the Sea, Fisheries, Evaluation, Social Aspects, Life Sciences, Agriculture, Food, Medicine, Health Type de contrat : Specific Targeted Research Project Participants : UNIVERSITEIT GENT BELGIQUE-BELGIË UNIVERSITEIT GENT Education UGENT, FACULTY OF VETERINARY MEDICINE, LABORATORY OF PARASITOLOGY Sint-Pietersnieuwstraat 25 BELGIQUE-BELGIË National Wool Growers' Association SOUTH AFRICA National Wool Growers' Association Other NWGA Training and Development Division PO Box 6055 41A Pickering Street, Newton Park 34291 SOUTH AFRICA SVANOVA BIOTECH AB SVERIGE SVANOVA BIOTECH AB Industry SVANOVA BIOTECH AB Uppsala Science Park SVERIGE Plantamedium GmbH DEUTSCHLAND Plantamedium GmbH Other Plantamedium GmbH Postfach 48231 Everswinkeler Str. 7 20 01 24 DEUTSCHLAND FRAENZ & JAEGER GMBH DEUTSCHLAND FRAENZ & JAEGER GMBH Industry FRÄNZ & JAEGER GMBH Schurzelter Strasse 27 DEUTSCHLAND UNIVERSITY OF BATH UNITED KINGDOM UNIVERSITY OF BATH Education DEPARTMENT OF BIOLOGY & BIOCHEMISTRY, UNIVERSITY OF BATH Claverton Down UNITED KINGDOM UNIVERSITY OF BRISTOL UNITED KINGDOM UNIVERSITY OF BRISTOL Education DEPARTMENT OF CLINICAL VETERINARY SCIENCE Senate House, Tyndall Avenue UNITED KINGDOM INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE FRANCE INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Research UNITÉ BIO-AGRESSEURS, SANTÉ, ENVIRONNEMENT (BASE) rue de l'Université 147 FRANCE STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER DEUTSCHLAND STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Education UNIVERSITY OF VETERINARY MEDICINE HANNOVER Buenteweg 2 DEUTSCHLAND SVERIGES LANTBRUKSUNIVERSITET SVERIGE SVERIGES LANTBRUKSUNIVERSITET Education DEPARTMENT OF BIOMEDICAL SCIENCES AND VETERINARY PUBLIC HEALTH, FACULTY OF VETERINARY MEDICINE AND ANIMAL SCIENCE, DIVISION OF PARASITOLOGY PO Box 7070 Arrheniusplan 2C SVERIGE MOREDUN RESEARCH INSTITUTE UNITED KINGDOM MOREDUN RESEARCH INSTITUTE Research MOREDUN RESEARCH INSTITUTE, PARASITOLOGY DIVISION, GENERAL PARASITOLOGY LABORATORY Pentland Science Park, Bush Loan, Penicuik UNITED KINGDOM PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES SLOVENSKA REPUBLIKA PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES Research PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES Hlinkova 3 SLOVENSKA REPUBLIKA University of Pretoria SOUTH AFRICA University of Pretoria Education Departments of Production Animal Studies and Veterinary Tropical Diseases, Faculty of Veterinary Science PO Box 0002 Lynnwood Road None SOUTH AFRICA INSTITUT AGRONOMIQUE ET VÉTÉRINAIRE HASSAN II MOROCCO INSTITUT AGRONOMIQUE ET VÉTÉRINAIRE HASSAN II Education DEPARTMENT OF PARASITOLOGY AND PARASITIC DISEASES PO Box 6202 Madinat Al Irfane MOROCCO ARISTOTELIO PANEPISTIMIO THESSALONIKIS HELLAS ARISTOTELIO PANEPISTIMIO THESSALONIKIS Education SCHOOL OF VETERINARY MEDICINE/ ARISTOTLE UNIVERSITY OF THESSALONIKI / LABORATORY OF PARASITOLOGY AND PARASITIC DISEASES Administration Building - University Campus HELLAS UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II ITALIA UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Research DEPARTMENT OF PATHOLOGY AND ANIMAL HEALTH, DIVISION OF PARASITOLOGY AND PARASITIC DISEASE Via della Veterinaria, 1 ITALIA FRAENZ & JAEGER Germany FRAENZ & JAEGER Industry FRÄNZ & JAEGER GMBH Schurzelter Strasse 27 Germany SVANOVA BIOTECH Sweden SVANOVA BIOTECH Industry SVANOVA BIOTECH AB Uppsala Science Park Sweden INNOVIS United Kingdom INNOVIS Industry INNOVIS Peithyll Centre, Capel Dewi United Kingdom Hide objective PARASOL focuses on gastro-intestinal nematode parasites of ruminants as they are the greatest threat to animal welfare and production, and since effective contributions can be made within three years. Current conventional methods for worm control involve repeated dosing of whole herds with synthetic anthelmintics but are unsustainable due to the food and environmental residues produced and promote the spread of anthelmintic resistance by failing to leave an untreated parasite refugium. Effective chemical anthelmintics remain irreplaceable for worm control and their elimination is not practical on animal welfare and economic grounds. We will replace current practice with Targeted Selective Treatments, where only animals showing clinical symptoms or reduced productivity are given drugs. Animals with low worm burdens are symptomless and do not require treatment. We will assess several innovative methods, under various farming conditions, for identifying animals that require treatment, and produce and standardise tests for anthelmintic resistance to ensure that the drugs are effective. We will produce, by the end of the project, clear guidance and protocols for sustainable, low-input, user- and consumer-friendly nematode control. In order to do this we will: (1) assess the effect of targeted selective treatments on productivity, animal welfare and the spread of anthelmintic resistance genes under a range of farming conditions; (2) determine the best methods of identifying animals and herds requiring anthelmintic intervention; (3) standardise existing in vivo and in vitro tests for detecting anthelmintic resistance and develop new tests for where current ones are inadequate; (4) optimise the efficacy and bio-availability of anthelmintics by modulating parasite P-glycoprotein detoxification systems; and (5) communicate with farmers, veterinarians and advisors, to produce and disseminate guidance to ensure good uptake and implementation of the protocols produced. Source : cordis