Philips Healthcare

Philips Medizin-Systeme Böblingen GmbH

Germany Private R&D centre
contact@expernova.com
Phone : (+49) 703 146 30
Mail : medizin.infoline@philips.com
Address :
Hewlett-Packard-Strasse 2
71034 Boeblingen
Germany
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Altered Cardiac Repolarization in Association with Air Pollution and Air Temperature among Myocardial Infarction Survivors
2010
Authors : Susanne Breitner, Irene Brüske, Josef CYRYS, Regina Hampel, Harald KORB, Annette Peters, Regina Rückerl, Alexandra E. SCHNEIDER, Jordi Sunyer, H.-Erich WICHMANN and Wojciech Zareba
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BACKGROUND: Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events. OBJECTIVE: We hypothesized that patients with previous myocardial infarction (MI) experience changes in heart rate (HR) and repolarization parameters, such as Bazett-corrected QT interval (QTc), and T-wave amplitude (Tamp), in association with increases in air pollution and temperature changes. METHODS: Between May 2003 and February 2004, 67 MI survivors from the Augsburg KORA-MI registry repeatedly sent 16 sec electrocardiograms (ECGs) with a personal transmitter (Viapac) via telephone to the Philips Monitoring Center, where ECG parameters were immediately analyzed. Meteorological data and air pollutants were acquired from fixed monitoring sites on an hourly basis. Additive mixed models were used for analysis. Effect modification by patient characteristics was investigated. RESULTS: The analysis of the 1,745 ECGs revealed an increased HR associated with interquartile range (IQR) increases in PM levels among participants not using beta-adrenergic receptor blockers and among those with body mass index ≥ 30 kg/m2. We observed a 24- to 47-hr lagged QTc prolongation [0.5% change (95% confidence interval, 0.0-1.0%)] in association with IQR increases in levels of PM ≤ 2.5 μm in aerodynamic diameter, especially in patients with one [0.6% (0.1-1.0%)] or two [1.2% (0.4-2.1%)] minor alleles of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) single-nucleotide polymorphism rs2364725. Positive immediate (0-23 hr) and inverse delayed (48-71 hr up to 96-119 hr) associations were evident between PM and Tamp. We detected an inverse U-shaped association between temperature and Tamp, with a maximum Tamp at 5°C. CONCLUSIONS: Increased air pollution levels and temperature changes may lead to changes in HR and repolarization parameters that may be precursors of cardiac problems.
Keywords :
Myocardial disease ; Coronary heart disease ; Cardiovascular disease ; Epidemiology ; Survivor ; Temperature ; Myocardial infarction ; Public health ; Health and environment ; Air pollution ; Human ; Heart ; Toxicity ; air pollution ; air temperature ; epidemiology ; myocardial infarction ; panel study ; repolarization ;
Source : Pascal - INIST  

Ultrasonographic monitoring and early diagnosis of stroke
UMEDS
2002 - 2005

Offers :
Scientific Research, Medicine, Health, Life Sciences
Participants :
Laboratoire Ondes et Acoustique
Laboratoire Ondes et Acoustique


Lecoeur Electronique
Lecoeur Electronique


Philips Healthcare
Philips Healthcare


Bracco Research
Bracco Research


Groupement D'interêt Public "ultrasons"
Groupement D'interêt Public "ultrasons"


Institut National de la Sante et de la Recherche Medicale
Institut National de la Sante et de la Recherche Medicale


Ruprecht-karls-universitaet Heidelberg
Ruprecht-karls-universitaet Heidelberg


Bracco Research SA
Bracco Research SA


Neurologische Klinik Der Ruhr - Universitaet Bochum
Neurologische Klinik Der Ruhr - Universitaet Bochum


University of Leicester
University of Leicester


University of Florence
University of Florence


University of Luebeck
University of Luebeck


RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DEUTSCHLAND
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Education,Other

NEUROLOGISCHE KLINIK - FAKULTAET FUER KLINISCHE MEDIZIN MANNHEIM PF 10 57 60 Theodor-Kutzer-Ufer 1-3 68167
DEUTSCHLAND
GROUPEMENT D'INTERÊT PUBLIC "ULTRASONS" FRANCE
GROUPEMENT D'INTERÊT PUBLIC "ULTRASONS"
Research,Other

B.P. 3223 Boulevard Tonnellé 2 BIS, Faculté de Médecine 37032
FRANCE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FRANCE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Research

U 494 - IMAGERIE MDICALE QUANTITATIVE Bld de l'H(pital 91 CHU PitiT-SalpOtriFre 75634
FRANCE
BRACCO RESEARCH SA SCHWEIZ/SUISSE/SVIZZERA
BRACCO RESEARCH SA
Industry

Route de la Galaise, 31 1228
SCHWEIZ/SUISSE/SVIZZERA
NEUROLOGISCHE KLINIK DER RUHR - UNIVERSITAET BOCHUM DEUTSCHLAND
NEUROLOGISCHE KLINIK DER RUHR - UNIVERSITAET BOCHUM
Education

c/o St Joseph Hospital - Gudrunstrasse, 56 44791
DEUTSCHLAND
UNIVERSITY OF LEICESTER UNITED KINGDOM
UNIVERSITY OF LEICESTER
Education

DEPARTMENT OF MEDICAL PHYSICS LEICESTER ROYAL INFIRMARY Infirmary Square LE1 5WW
UNITED KINGDOM
UNIVERSITY OF FLORENCE ITALIA
UNIVERSITY OF FLORENCE
Education

ELECTRONIC AND TELECOMMUNICATION DEPARTMENT S Marta, 3 50139
ITALIA
UNIVERSITY OF LUEBECK DEUTSCHLAND
UNIVERSITY OF LUEBECK
Education

KLINIK FUER NEUROLOGIE Ratzeburger Allee 160 23538
DEUTSCHLAND
Hide objectives
The UMEDS project will establish non-invasive techniques for early diagnosis and bedside monitoring of stroke to improve stroke outcome. An important goal will be to expand recent developments in microbubble technology and ultrasonographic harmonic imaging to establish ultrasound techniques for both qualitative and quantitative evaluation of brain perfusion. UMEDS will develop new technologies to meet these goals. These include an automated system for detection of microemboli, a device for imaging the brain through the skull, a dual transducer system for microemboli detection and enhanced features for commercial applications of ultrasound perfuson imaging. We will investigate novel targeted microbubble technology for characterizing microemboli.

Source : Cordis  





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