Phadia

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	Quelques documents de Phadia
	Influence of the dietary history in the prevention of coeliac disease: possibilities of induction of tolerance for gluten in genetic predisposed children PREVENTCD 2007 - 2010 Sujets : Food Other Indexes:Breast,Breast-feeding,Coeliac disease,Early nutrition,Food industry,Genetics,Immune response,Prevention,Tolerance,Treatment,feeding,Gluten Type de contrat : Specific Targeted Research Project Participants : ACADEMISCH ZIEKENHUIS LEIDEN ACTING UNDER THE NAME LEIDS UNIVERSITAIR MEDISCH CENTRUM NEDERLAND ACADEMISCH ZIEKENHUIS LEIDEN ACTING UNDER THE NAME LEIDS UNIVERSITAIR MEDISCH CENTRUM DEPARTMENT OF PAEDIATRICS DEPARTMENT OF IMMUNOHAEMATOLOGY AND BLOOD TRANSFUSION PO Box 9600 Albinusdreef 2 NEDERLAND CHILDREN'S HOSPITAL ZAGREB, ZAGREB MEDICAL SCHOOL Hrvatska CHILDREN'S HOSPITAL ZAGREB, ZAGREB MEDICAL SCHOOL REFERRAL CENTER FOR PAEDIATRIC GASTROENTEROLOGY AND NUTRITION Klaiceva 16 Hrvatska UNIVERSITETET I OSLO NORGE UNIVERSITETET I OSLO INSTITUTE OF IMMUNOLOGY 1072 Blindern Problemvei 7 NORGE FUNDACION HOSPITAL LA FE ESPAÑA FUNDACION HOSPITAL LA FE PEDIATRIC GASTROENTEROLOGY UNIT HOSPITAL LA FE PEDIATRIC GASTROENTEROLOGY UNIT HOSPITAL LA FE Avenida Campanar 21 ESPAÑA DANONE RESEARCH B.V. NEDERLAND DANONE RESEARCH B.V. Industry DANONE RESEARCH BV PO Box 7005 Bosrandweg 20 NEDERLAND PHADIA GMBH DEUTSCHLAND PHADIA GMBH Industry CORE PROCESS ASSAY VARELISA 2 Postfach 1050 Munzinger Strasse 7 DEUTSCHLAND LUDWIG MAXIMILIANS UNIVERSITY DEUTSCHLAND LUDWIG MAXIMILIANS UNIVERSITY DR. V. HAUNERSCHES KINDERSPITAL, DIV. GASTROENTEROLOGY AND HEPATOLOGY Geschwister Scholl Platz 1 DEUTSCHLAND FÖVÁROSI ÖNKORMÁNYZAT HEIM PÁL GYERMEKKÓRHÁZ MAGYARORSZAG FÖVÁROSI ÖNKORMÁNYZAT HEIM PÁL GYERMEKKÓRHÁZ COELIAKIA CENTRUM (COELIAC DISEASE CENTER) KÖZPONTI LABORATÓRIUM (CENTRAL LABORATORY-BLOOD SAMPLING) Üllöi út 86 MAGYARORSZAG AKADEMIA MEDYCZNA W WARSZAWIE POLSKA AKADEMIA MEDYCZNA W WARSZAWIE DEPARTMENT OF PAEDIATRIC GASTROENTEROLOGY AND NUTRITION Zwirki i Wigury 61 POLSKA UNIVERSITY OF NAPLES FEDERICO II ITALIA UNIVERSITY OF NAPLES FEDERICO II ELFID (EUROPEAN LABORATORY FOR THE INVESTIGATION OF FOOD INDUCED DISEASES) Via Sergio Pansini 5 ITALIA UNIVERSITAT ROVIRA I VIRGILI ESPAÑA UNIVERSITAT ROVIRA I VIRGILI DEPARTAMENTA DE MEDICINA Y CIRUGIA. FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT C. de l' Escorxador, s/n ESPAÑA HOSPITAL UNIVERSITARIO LA PAZ ESPAÑA HOSPITAL UNIVERSITARIO LA PAZ DEPARTMENT FOR PAEDIATRIC GASTROENTEROLOGY AND NUTRITION Paseo de la Castellana 261 ESPAÑA UMEA UNIVERSITET SVERIGE UMEA UNIVERSITET EPIDEMIOLOGY AND PUBLIC HEALTH SCIENCES DEPT. OF PUBLIC HEALTH AND CLINICAL MEDICINE Universitetsomraadet SVERIGE ASSOCIATION OF EUROPEAN COELIAC SOCIETIES BELGIQUE-BELGIË ASSOCIATION OF EUROPEAN COELIAC SOCIETIES Other AOECS c/o Societe belge de la Coeliaquie, Rue des Waides 9 BELGIQUE-BELGIË TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY ISRAEL TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY BRUCE RAPPAPORT SCHOOL OF MEDICINE/ MEYER CHILDREN'S HOSPITAL OF HAIFA/ PEDIATRIC GASTROENTEROLOGY AND NUTRITION Technion city ISRAEL UNIVERSITAL HOSPITAL GRONINGEN / UNIVERSITY MEDICAL CENTER GRONINGEN NEDERLAND UNIVERSITAL HOSPITAL GRONINGEN / UNIVERSITY MEDICAL CENTER GRONINGEN DEPARTMENT OF GENETICS PO Box 30001 Hanzeplein 1 NEDERLAND PHADIA Germany PHADIA Industry CORE PROCESS ASSAY VARELISA 2 Postfach 1050 Munzinger Strasse 7 Germany DANONE RESEARCH Netherlands DANONE RESEARCH Industry DANONE RESEARCH BV PO Box Bosrandweg 20 Netherlands EUROSPITAL Italy EUROSPITAL Industry EUROSPITAL SPA Via Flavia 122 Italy Hide objective Coeliac disease (CD) is a chronic disorder caused by hypersensitivity to some of the most common proteins (gluten) in the diet of the European population. CD affects as much as 1% of the Europeans (2.5 million people) and is the most common food intolerance in Europe. If recognised, CD patients have only limited access to safe foods and there is no causal therapy available. The general objective of this STREP is to significantly reduce the number of people suffering from CD in Europe, by developing primary prevention strategies for CD. By European collaboration of leaders from disciplines beyond those traditionally used, a.o. from academia, patient organisations and industry, we will carry out innovative research to examine the hypothesis that it is possible to induce tolerance for gluten in genetically predisposed children through the introduction of small quantities of gluten during the period of breast-feeding. Measurable objectives are: 1) Taking full advantage of genomics techniques: Identification of the immunological mechanisms involved in initiating the aberrant response to gluten introduction in the diet of infants genetically predisposed to CD; 2) Identification of the factors in the early dietary history involved in the aberrant response to gluten in children; 3) Development of new European guidelines for early nutrition in order to prevent CD. To achieve our objectives we propose the following structure and methodology: I) A prospective, randomized, blind dietary intervention study in 1000 young children from high-risk families for CD , to asses the possibilities to induce immune tolerance for gluten in genetically predisposed children; II) A follow-up population study in 16.000 children aged 12 years, born during and after the Swedish epidemic of CD, to asses the late effect of dietary history, concerning gluten exposure and breast-feeding, on the development of CD and related autoimmune phenomena. Source : cordis