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Quelques documents de Pci Biotech
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Targeted delivery of nanomedicine
MEDITRANS Sujets :
Medicine, Health, Industrial Manufacture, Materials Technology
Type de contrat :
Integrated Project
Participants :
UNIVERSITEIT UTRECHT NEDERLAND
UNIVERSITEIT UTRECHT
DEPARTMENT OF PHARMACEUTICAL SCIENCES PO Box 80125 HEIDELBERGLAAN 8 NEDERLAND
BAYER SCHERING PHARMA AG DEUTSCHLAND
BAYER SCHERING PHARMA AG
PHZE, DRUG DELIVERY SYSTEMS / CMC-TO MULLERSTRASSE 178 DEUTSCHLAND
PHILIPS TECHNOLOGIE GMBH FORSCHUNGSLABORATORIEN DEUTSCHLAND
PHILIPS TECHNOLOGIE GMBH FORSCHUNGSLABORATORIEN
PHILIPS RESEARCH LABORATORIES-HAMBURG SECTOR TECHNICAL SYSTEMS Postfach 500145 WEISSHAUSSTR. 2 DEUTSCHLAND
INTEGRATED DNA TECHNOLOGIES BVBA BELGIQUE-BELGIË
INTEGRATED DNA TECHNOLOGIES BVBA
Building Vendome, Culligan Laan 1b BELGIQUE-BELGIË
UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA ESPAÑA
UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA
INSTITUTO UNIVERSITARIO DE INVESTIGACION CALLE BRAVO MURILLO, 38 ESPAÑA
UNIVERSITÀ DEGLI STUDI DI TORINO ITALIA
UNIVERSITÀ DEGLI STUDI DI TORINO
DIPARTIMENTO DI CHIMICA I.F.M. Via Verdi, 8 ITALIA
RIJKSUNIVERSITEIT GRONINGEN NEDERLAND
RIJKSUNIVERSITEIT GRONINGEN
DEPARTMENT OF BIOCHEMISTRY, GRONINGEN BIOMOLECULAR SCIENCES AND BIOTECHNOLOGY INSTITUTE, FACULTY OF MATHEMATICS AND NATURAL SCIENCES Broerstraat 5 NEDERLAND
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ESPAÑA
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
DEPARTMENT OF BIOMOLECULAR STRUCTURE AND FUNCTION / INSTITUTE OF BIOMEDICAL RESEARCH "ALBERTO SOLS" / LABORATORY OF IMAGING AND SPECTROSCOPY BY MR LISMAR SERRANO 117 ESPAÑA
TECHNISCHE UNIVERSITEIT EINDHOVEN NEDERLAND
TECHNISCHE UNIVERSITEIT EINDHOVEN
DEPARTMENT OF BIOMEDICAL ENGINEERING PO Box 513 DEN DOLECH 2 5612 AZ NEDERLAND
PCI BIOTECH AS NORGE
PCI BIOTECH AS
HOFFSVEIEN 48 NORGE
INFUTURIA GROUP AG SCHWEIZ/SUISSE/SVIZZERA
INFUTURIA GROUP AG
INFUTURIA GROUP AG Rotfluhstrasse 85 SCHWEIZ/SUISSE/SVIZZERA
WEIZMANN INSTITUTE OF SCIENCE ISRAEL
WEIZMANN INSTITUTE OF SCIENCE
BIOLOGICAL REGULATION / BIOLOGY / WEIZMANN INSTITUTE OF SCIENCE HERZL ST. ISRAEL
UNIVERSITAIR MEDISCH CENTRUM UTRECHT NEDERLAND
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
DEPARTMENT OF RADIOLOGY AND NUCLEAR MEDICINELUIJTEN PO Box 85500 Heidelberglaan 100 NEDERLAND
COMMISSARIAT A L'ENERGIE ATOMIQUE FRANCE
COMMISSARIAT A L'ENERGIE ATOMIQUE
LABORATORY OF INNOVATION FOR NEW ENERGY TECHNOLOGIES AND NANOMATERIALS (LITEN) 15 rue Leblanc FRANCE
COPENHAGEN UNIVERSITY DANMARK
COPENHAGEN UNIVERSITY
DEPARTMENT OF PHARMACEUTICS AND ANALYTICAL CHEMISTRY Noerregade 10 DANMARK
STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM NEDERLAND
STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM
AMOLF: FOM-INSTITUTE FOR ATOMIC AND MOLECULAR PHYSICS PO Box 3021 VAN VOLLENHOVENSTRAAT 659 NEDERLAND
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE FRANCE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IMAGERIE MOLECULAIRE ET FONCTIONNELLE: DE LA PHYSIOLOGIE A LA THERAPIE/CNRS/UNIVERSITE VICTOR SEGALEN BORDEAUX 2 3 rue Michel-Ange FRANCE
MAGFORCE NANOTECHNOLOGIES AG DEUTSCHLAND
MAGFORCE NANOTECHNOLOGIES AG
R AND D SPANDAUER DAMM 130, HAUS 30, CBN DEUTSCHLAND
STICHTING BIOMADE TECHNOLOGY NEDERLAND
STICHTING BIOMADE TECHNOLOGY
BIOMADE TECHNOLOGY FOUNDATION NIJENBORGH 4 NEDERLAND
UNIVERSITEIT GENT BELGIQUE-BELGIË
UNIVERSITEIT GENT
FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICS Sint Pietersnieuwstraat 25 BELGIQUE-BELGIË
N. V. ORGANON NEDERLAND
N. V. ORGANON
DEPARTMENT OF PHARMACEUTICS MOLENSTRAAT 110 NEDERLAND
PHILIPPS-UNIVERSITÄT MARBURG DEUTSCHLAND
PHILIPPS-UNIVERSITÄT MARBURG
DEPARTMENT OF PHARMACEUTICS AND BIOPHARMACY BIEGENSTRASSE 10 DEUTSCHLAND
ACROSS BARRIERS GMBH DEUTSCHLAND
ACROSS BARRIERS GMBH
ACROSS BARRIERS GMBH SCIENCE PARK 1 DEUTSCHLAND
MERCK-SERONO SA SCHWEIZ/SUISSE/SVIZZERA
MERCK-SERONO SA
MERCK SERONO S.A. - GENEVA 9, chemin des Mines SCHWEIZ/SUISSE/SVIZZERA
UNIWERSYTET LÓDZKI POLSKA
UNIWERSYTET LÓDZKI
DEPARTMENT OF MOLECULAR BIOPHYSICS -MEMBRANE BIOPHYSICS LAB NARUTOWICZA 65 POLSKA
UNIVERSITÄT DES SAARLANDES DEUTSCHLAND
UNIVERSITÄT DES SAARLANDES
DEPT. BIOPHARMACEUTICS AND PHARMACEUTICAL TECHNOLOGY Postfach 15 11 50 UNIVERSITY CAMPUS DEUTSCHLAND
CHARITE UNIVERSITATSMEDIZIN BERLIN DEUTSCHLAND
CHARITE UNIVERSITATSMEDIZIN BERLIN
CENTER FOR BIOMEDICAL NANOTECHNOLOGY AT THE KLINIK FUR STRAHLENHEILKUNDE (CLINIC FOR RADIOTHERAPEUTICS) SCHUMANNSTRASSE 20-21 DEUTSCHLAND
PHILIPS ELECTRONICS NEDERLAND B.V. NEDERLAND
PHILIPS ELECTRONICS NEDERLAND B.V.
PHILIPS RESEARCH LABORATORIES EINDHOVEN 5621 JG BOSCHDIJK 525 NEDERLAND
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPMENT SCHWEIZ/SUISSE/SVIZZERA
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPMENT
CSEM NANOTECHNOLOGY AND LIFE SCIENCE JAQUET DROZ 1 SCHWEIZ/SUISSE/SVIZZERA
INTEGRATED DNA TECHNOLOGIES BVBA Belgium
INTEGRATED DNA TECHNOLOGIES BVBA
Building Vendome, Culligan Laan 1b Belgium
ACROSS BARRIERS Germany
ACROSS BARRIERS
ACROSS BARRIERS GMBH SCIENCE PARK 1 Germany
BAYER SCHERING PHARMA Germany
BAYER SCHERING PHARMA
PHZE, DRUG DELIVERY SYSTEMS / CMC-TO MULLERSTRASSE 178 Germany
MAGFORCE NANOTECHNOLOGIES Germany
MAGFORCE NANOTECHNOLOGIES
R AND D SPANDAUER DAMM 130, HAUS 30, CBN Germany
PHILIPS TECHNOLOGIE FORSCHUNGSLABORATORIEN Germany
PHILIPS TECHNOLOGIE FORSCHUNGSLABORATORIEN
PHILIPS RESEARCH LABORATORIES-HAMBURG SECTOR TECHNICAL SYSTEMS Postfach 5 WEISSHAUSSTR. 2 Germany
PCI BIOTECH Norway
PCI BIOTECH
HOFFSVEIEN 48 Norway
MERCK SERONO Switzerland
MERCK SERONO
MERCK SERONO S.A. - GENEVA Chemin des Mines, 9 Switzerland
PHILIPS ELECTRONICS NEDERLAND Netherlands
PHILIPS ELECTRONICS NEDERLAND
PHILIPS RESEARCH LABORATORIES EINDHOVEN, CARE AND HEALTH APPLICATIONS PO Box 0 Boschdijk 525 ( please use for correspondence : Prof. Holstlaan 4, 5656 AA Eindhoven ) Netherlands
BRACCO IMAGING Italy
BRACCO IMAGING
Via Egidio Folli, 50 Italy
ISTITUTO DI RICERCHE BIOMEDICHE ANTOINE MARXER RBM Italy
ISTITUTO DI RICERCHE BIOMEDICHE ANTOINE MARXER RBM
DEPARTMENT OF PHARMACOLOGY VIA RIBES 1 Italy
MOLECULAR PROFILES United Kingdom
MOLECULAR PROFILES
MOLECULAR PROFILES 8 ORCHARD PLACE United Kingdom
MEDITRANS will develop systems for targeted delivery of nanomedicines, which will be broadly applicable to disease. The focus is on chronic inflammatory disorders and cancer. Such industrially developed targeted products will improve therapy and in vivo visualisation of drug delivery/release processes.Nanocarriers (nanoparticles, nanotubes, fullerenes), endowed with high targeting capabilities, will be designed in parallel with MRI probes that report on localisation of the targeted nanoparticulates, specific bio-markers, and the drug release process (MRI-guided drug delivery).For reproducible behaviour in vivo, these nanomedicines containing drug payloads (e.g. pDNA, siRNA, small molecular weight agents) will have their physicochemical/stability properties characterised. 'Smart' delivery systems, tested in vitro, able to recognise the target, and to cross-relevant biological barriers, will be investigated for their responsiveness to the microenvironment of the target site (e.g. local pH).Control of drug re lease, triggered by external physical means (e.g. temperature, light, magnetism, ultrasound) or by local stimuli within the pathological site (e.g. pH, enzymatic activity) will be investigated in vitro. Ways to direct the intracellular trafficking of nanocarriers, to achieve improved interaction with the intracellular target location, will be investigated.In vivo applicability will be evaluated in clinically relevant models of disease. Toxicology aspects, industrial scale-up feasibility, long term stability, and feasibility to prepare clinical grade material will be covered.Dissemination, training and exploitation will be done. MEDITRANS, duration 4 years, is a timely, interdisciplinary IP at the forefront of targeted nanomedicine, with a budget of 16.1M Euro, a grant of 11M Euro (68%), and 1581.75 person-months effort.The 30 partners (12 European countries) are from industry (8), SMEs (5), universities (11), and research institutes (6).
Source :
cordis
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