Ebit Aet

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	Quelques documents de Ebit Aet
	Systems for in-situ theranostics using micro-particles triggered by ultrasound S.I.G.H.T. 2006 - 2009 Sujets : Electronics, Microelectronics, Information Processing, Information Systems, Telecommunications Type de contrat : Specific Targeted Research Project Participants : CONSORZIO ROMA RICERCHE ITALIA CONSORZIO ROMA RICERCHE Research VIA ARDITO DESIO 60 00131 ITALIA KUNGLIGA TEKNISKA HOGSKOLAN SVERIGE KUNGLIGA TEKNISKA HOGSKOLAN Education VALHALLAVAGEN 79 100 44 SVERIGE UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN ÉIRE/IRELAND UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Education BELFIELD ÉIRE/IRELAND CAPSULUTION NANOSCIENCE AG DEUTSCHLAND CAPSULUTION NANOSCIENCE AG Industry VOLMERSTRASSE 7 B 12489 DEUTSCHLAND UNIVERSITAET BAYREUTH DEUTSCHLAND UNIVERSITAET BAYREUTH Education,Other UNIVERSITAETSSTRASSE 30 95447 DEUTSCHLAND FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI ITALIA FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Education VIA GIACOMO VENEZIAN 1 20133 ITALIA MEDTRONIC BAKKEN RESEARCH CENTER B.V. NEDERLAND MEDTRONIC BAKKEN RESEARCH CENTER B.V. Industry ENDEPOLSDOMEIN 5 6229GW NEDERLAND EBIT AET S.P.A. ITALIA EBIT AET S.P.A. Other VIA SIFFREDI ANGELO 58 16153 ITALIA UNIVERSITA DEGLI STUDI DI ROMA "TOR VERGATA" ITALIA UNIVERSITA DEGLI STUDI DI ROMA "TOR VERGATA" Education VIA ORAZIO RAIMONDO 18 00173 ITALIA KAROLINSKA INSTITUTET SVERIGE KAROLINSKA INSTITUTET Education NOBELS VAEG 5 171 77 SVERIGE CAPSULUTION NANOSCIENCE Germany CAPSULUTION NANOSCIENCE Industry VOLMERSTRASSE 7 B Germany MEDTRONIC BAKKEN RESEARCH CENTER Netherlands MEDTRONIC BAKKEN RESEARCH CENTER Industry BIOMATERIALS TECHNOLOGY Endepolsdomein 5 Netherlands Hide objective A contrast agent is any substance able to enhance the information contained in an image derived from a medical diagnostic instrumentation concerning the traditional or digital radiology entailing the magnetic resonance, nuclear medicine, and last but not least ultrasound. The contrast agents can be administered orally or injected in the systemic circulation. Ultrasound contrast agents (UCAs) consist in dispersions of microbubbles containing air or other gases that can reflect efficiently ultrasound waves during an echo-tomographic investigation. S.I.G.H.T., "Systems for in-situ theranostics using micro-particles triggered by ultrasound", is a project focused on the design of multifunctional UCAs as supporting devices for theranostics, i.e. for both diagnostic and therapeutic treatments, delivering drug to the right place in the body, in pathologies as thrombosis, tissue repearing and cancer therapies. The research activities of the project will concern the formulation of the devices (microballoons and microcapsules), their ultrasound and mechanical properties, tagging of the device outer surface with specific molecules for a target tissue or organ, bioadhesion and biocompatibility tests, drug release properties of the devices upon insonification of coronary artery smooth muscle, endothelial cells, clots (sonothrombolysis), hepatocellular carcinoma and colon cancer cells. Image processing and reconstruction derived from the ultrasound devices will be carried out with the design of ad hoc hardware and software. Exploitation of microballoons and microcapsules in ex situ applications will be also tackled by formulating self - assembled microarrays for high throughput analysis. A dissemination and exploitation activity will be carried out with the final release of a prototype acting on a mimicking phantom of an organ and with the supporting know-how for "next step" actions as validation plan and pre-competitive industrialization. Source : cordis