Ebiochip Systems

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	Téléphone : Mail : Adresse : DEPT. R&D Fraunhoferstr.1 Itzehoe Allemagne Web : http://www.ebiochip.com

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	Quelques documents de Ebiochip Systems
	Capture and enrichment of emerging pathogens for multiple and ultra-sensitive diagnostic USDEP 2006 - 2010 Sujets : Medicine, Health, Biotechnology, Life Sciences Type de contrat : Specific Targeted Research Project Participants : ROBERT KOCH-INSTITUT DEUTSCHLAND ROBERT KOCH-INSTITUT Research ROBERT KOCH-INSTITUT Nordufer 20 DEUTSCHLAND PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE CHILE PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE CENTRO DE INVESTIGACIONES MEDICAS/FACULTAD DE MEDICINA/PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE/LABORATORIO DE VIROLOGIA MOLECULAR 114-D Avenida del Libertador Bernardo O'Higgins 340 CHILE FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DEUTSCHLAND FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Other FRAUNHOFER-INSTITUT FÜR SILIZIUMTECHNOLOGIE (ISIT) Hansastrasse 27 C DEUTSCHLAND INSTITUT DE RECHERCHES POUR LE DÉVELOPPEMENT FRANCE INSTITUT DE RECHERCHES POUR LE DÉVELOPPEMENT UR MALADIES VIRALES EMERGENTES/LABORATOIRE D'IMMUNOLOGIE RÉTROVIRALE ET MOLÉCULAIRE' 44, Bd de Dunkerke, CS 90009 FRANCE GENEXPRESS GESELLSCHAFT FÜR PROTEINDESIGN GMBH DEUTSCHLAND GENEXPRESS GESELLSCHAFT FÜR PROTEINDESIGN GMBH GENEXPRESS GESELLSCHAFT FÜR PROTEINDESIGN Eresburgstr. 22-23 DEUTSCHLAND EBIOCHIP SYSTEMS GMBH DEUTSCHLAND EBIOCHIP SYSTEMS GMBH Industry DEPT. R&D Fraunhoferstr.1 DEUTSCHLAND APOH TECHNOLOGIES France APOH TECHNOLOGIES Industry APOH TECHNOLOGIES 94 Allée des Fauvettes France SA SKULD TECH France SA SKULD TECH Industry SKULD-TECH/CONTROLIFE 134 rue du Curat - Immeuble Amarante France EBIOCHIP SYSTEMS Germany EBIOCHIP SYSTEMS Industry DEPT. R&D Fraunhoferstr.1 Germany IMMUNOCLIN United Kingdom IMMUNOCLIN Industry IMMUNOCLIN LIMITED Rowlandson House 289 to 293 Ballards lane United Kingdom Hide objective In the 1970's WHO proclaimed that eradication of smallpox should be attempted. This goal has been achieved 1979. There is now consensus that list of newly emerging or re-emerging pathogens is continuously growing. During the last decades pathogens such as Marburg, Ebola, Hepatitis-C and Hantavirus, HIV and more recently, SARS coronavirus have emerged. Today the risk of a new influenza pandemic again highlights the global threat of infectious diseases. In addition, the possibility of bioterrorist attacks using highly pathogenic viruses and bacteria can not be ignored. Furthermore, the requirements for sensitivity and specifity of diagnostics have increased. A major obstacle for the detection of pathogens in clinical or environmental samples are false negative results, e.g. for HCV "occult infections". This is mainly due to the lack of a rapid and reliable pathogen concentration methodology, and the inability of most of the currently used technologies to eliminate or neutralize interfering "natural inhibitors" present in samples. The aim of this research program is to exploit the "non-self" recognition and binding properties of human apolipoprotein H (ApoH). ApoH binds and captures pathogens enabling their concentration from different biological samples. Magnetic beads coated with ApoH recombinant protein can be efficiently used as a pretreatment step to greatly improve the detection threshold and thereby increasing the sensitivity for diagnosis of emerging pathogens, regardless of the molecular techniques used for their diagnosis. The project will focus on viruses and bacteria from clinical and environmental samples including those that could be used in bioterrorism. In addition to the incorporation of ApoH into regular molecular techniques for pathogen detection, mini-array chips will be developed for multiple and ultra-sensitive pathogen diagnosis.' Source : cordis