Ebi Foodfety

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	Quelques documents de Ebi Foodfety
	Salmonella-free broilers by live vaccine-induced innate resistance to colonisation and invasion and novel methods to eliminate vaccine and field strains SUPASALVAC 2004 - 2008 Sujets : Life Sciences, Medicine, Health, Agriculture, Food, Resources of the Sea, Fisheries Other Indexes:Immunity,safety,Food,Salmonella,Chicken,Food-safety Type de contrat : Specific Targeted Research Project Participants : INSTITUTE FOR ANIMAL HEALTH UNITED KINGDOM INSTITUTE FOR ANIMAL HEALTH INSTITUTE FOR ANIMAL HEALTH UNITED KINGDOM VETERINARY RESEARCH INSTITUTE CESKA REPUBLIKA VETERINARY RESEARCH INSTITUTE Research VETERINARY RESEARCH INSTITUTE Hudcova 70 CESKA REPUBLIKA FRIEDRICH-LÖFFLER-INSTITUT, FEDERAL RESEARCH CENTER FOR VIRUS DISEASES OF ANIMALS DEUTSCHLAND FRIEDRICH-LÖFFLER-INSTITUT, FEDERAL RESEARCH CENTER FOR VIRUS DISEASES OF ANIMALS FEDERAL RESEARCH CENTER FOR VIRUS DISEASES OF ANIMALS Boddenblick 5 A DEUTSCHLAND EBI B.V. NEDERLAND EBI B.V. Other EBI B.V. De Savornin Lohmanlaan 224 NEDERLAND ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B.V. NEDERLAND ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B.V. Research ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B.V. Edelhertweg 15 NEDERLAND VETERINARY MEDICAL RESEARCH INSTITUE - HUNGARIAN ACADEMY OF SCIENCES MAGYARORSZAG VETERINARY MEDICAL RESEARCH INSTITUE - HUNGARIAN ACADEMY OF SCIENCES Research VETERINARY MEDICAL RESEARCH INSTITUE - HUNGARIAN ACADEMY OF SCIENCES Hungaria krt. 21 MAGYARORSZAG LOHMANN ANIMAL HEALTH GMBH & CO. KG DEUTSCHLAND LOHMANN ANIMAL HEALTH GMBH & CO. KG Other LOHMANN ANIMAL HEALTH GMBH & CO. KG Heinz-Lohmann-Strasse 4 DEUTSCHLAND EBI FOOD SAFETY BV NEDERLAND EBI FOOD SAFETY BV Other Nieuwe Kanal 7P NEDERLAND UNIVERSITY OF BRISTOL UNITED KINGDOM UNIVERSITY OF BRISTOL Education UNIVERSITY OF BRISTOL BS8 1TH Senate House, Tyndall Avenue UNITED KINGDOM THE UNIVERSITY OF NOTTINGHAM UNITED KINGDOM THE UNIVERSITY OF NOTTINGHAM SCHOOL OF VETERINARY MEDECINE AND SCIENCE University Park UNITED KINGDOM UNIVERSITEIT GENT BELGIQUE-BELGIË UNIVERSITEIT GENT Education UNIVERSITEIT GENT Sint Pietersnieuwstraat 25 BELGIQUE-BELGIË STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK NEDERLAND STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK CENTRAL VETERINARY INSTITUTE, FORMER INFECTIOUS DISEASES DIVISION OF THE ANIMAL SCIENCE GROUP, PART OF DLO PO Box 9101 Costerweg 50 NEDERLAND INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE FRANCE INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Research INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Rue de l'Universite 147 FRANCE Hide objective Salmonella in broiler poultry remains the major source of infection for man and is the least tractable because of the young age at which broilers are slaughtered and their immunological immaturity. In previous project (FAIR 98-4006) we have found that intestinal colonisation of newly hatched chicks with live, attenuated Salmonella vaccine strains results in the development of a rapid and profound resistance to intestinal infection (from a specific microbiological exclusion mechanism) and also to tissue invasion (from an induction of heterophil infiltration into the intestine). We will exploit these phenomena by screening strains of Salmonella stereotypes Typhimurium, Entertains and Hagar for these phenotypes, introducing attenuating mutations and assessing their protective effect in broilers under experimental and simulated field conditions. The degree of attenuation induced and the host cell responses to the vaccines will also be studied. In addition, we will explore the potential of new biotechnological approaches for the elimination of pathogenic bacteria (wild-type and vaccine strains) from the chicken intestine by a) identifying colonisation genes in Salmonella and mutating them, b) exploring the potential of introducing inducible bacterial suicide genes into Salmonella c) studying hostdefensin production in the intestine and its induction by vaccines d) dietary manipulation to modulate expression of invasion genes. Microarray technology will be used to identify colonisation andheterophil-induction genes and examine host responses. We will also exploit our expertise in phage technology to explore the use of bacteriophages to control intestinal infection and reduce carcass contamination by Salmonella and use these in association with vaccine strains totes a combined approach to pathogen elimination. Source : cordis