Cxr Biosciences
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Quelques documents de Cxr Biosciences
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European Rat Tools for Functional Genomics
EURATOOLS Sujets :
Life Sciences, Biotechnology
Type de contrat :
Integrated Project
Participants :
MEDICAL RESEARCH COUNCIL UNITED KINGDOM
MEDICAL RESEARCH COUNCIL
MRC CLINICAL SCIENCES CENTRE (CSC) 20 Park Crescent UNITED KINGDOM
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE FRANCE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
UMR BIOLOGIE DU DÉVELOPPEMENT ET REPRODUCTION 147 rue de l'Université FRANCE
UNIVERSITAT AUTÒNOMA DE BARCELONA ESPAÑA
UNIVERSITAT AUTÒNOMA DE BARCELONA
DEPT.OF PSYCHIATRY AND FORENSIC MEDICINE/SCHOOL OF MEDICINE/INSTITUTE OF NEUROSCIENCE/MEDICAL PSYCHOLOGY UNIT CAMPUS UNIVERSITARI, S/N ESPAÑA
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FRANCE
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
CEA - INSTITUT DE GENOMIQUE - CENTRE NATIONAL DE GENOTYPAGE Batiment Le Ponant D - 25 rue Le Blanc FRANCE
KAROLINSKA INSTITUTET SVERIGE
KAROLINSKA INSTITUTET
NEUROIMMUNOLOGY UNIT, DEPARTMENT OF CLINICAL NEUROSCIENCES, KAROLINSKA INSTITUTET Nobels väg 5 SVERIGE
INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES CHINA
INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
STATE KEY LABORATORY OF REPRODUCTIVE BIOLOGY, INSTITUTE OF ZOOLOGY 25 Beisihuanxi road CHINA
LUNDS UNIVERSITET SVERIGE
LUNDS UNIVERSITET
CMB/MED/MEDICAL INFLAMMATION RESEARCH PO Box 117 Paradisgatan 5C SVERIGE
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UNITED KINGDOM
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
WELLCOME TRUST CENTRE FOR HUMAN GENETICS NOT APPLICABLE University Offices, Wellington Square UNITED KINGDOM
THE UNIVERSITY OF EDINBURGH UNITED KINGDOM
THE UNIVERSITY OF EDINBURGH
MOLECULAR PHYSIOLOGY, UNIVERSITY OF EDINBURGH Old College, South Bridge UNITED KINGDOM
UNIVERSITE LIBRE DE BRUXELLES BELGIQUE-BELGIË
UNIVERSITE LIBRE DE BRUXELLES
INSTITUT DE BIOLOGIE ET DE MEDECINE MOLECULAIRES, LABORATOIRE DE BIOLOGIE DU DÉVELOPPEMENT Avenue Franklin D. Roosevelt 50 BELGIQUE-BELGIË
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. DEUTSCHLAND
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
PROSCIENCE Hofgartenstr. 8 DEUTSCHLAND
UNIVERSITY OF GLASGOW UNITED KINGDOM
UNIVERSITY OF GLASGOW
DIVISION OF CARDIOVASCULAR MEDICAL SCIENCES University Avenue UNITED KINGDOM
EUROPEAN MOLECULAR BIOLOGY LABORATORY DEUTSCHLAND
EUROPEAN MOLECULAR BIOLOGY LABORATORY
EUROPEAN BIOINFORMATICS INSTITUTE Meyerhofstraße 1 DEUTSCHLAND
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN DEUTSCHLAND
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
FUNCTIONAL GENETICS AND GENOMICS GROUP Robert-Rössle-Str. 10 DEUTSCHLAND
INSTITUTE OF PHYSIOLOGY, CZECH ACADEMY OF SCIENCES CESKA REPUBLIKA
INSTITUTE OF PHYSIOLOGY, CZECH ACADEMY OF SCIENCES
INSTITUTE OF PHYSIOLOGY, CZECH ACADEMY OF SCIENCES Videnska 1083 CESKA REPUBLIKA
CXR BIOSCIENCES United Kingdom
CXR BIOSCIENCES
CXR BIOSCIENCES LTD. Dundee Technopole, James Lindsay Place United Kingdom
Determining the molecular basis of natural phenotypic variation, including inter-individual susceptibility to common diseases, is a central challenge of post-genome genetics. The rat is a leading model species for research in physiology, pharmacology and toxicology, and for the study of a wide range of common, genetically complex human diseases. Decades of exquisite phenotyping and detailed analyses in rat experimental crosses have led to localization of hundreds of quantitative trait loci (QTLs) contai ning genes that confer susceptibility to complex disease phenotypes. However in common with studies in other organisms, few genes underlying these genetically complex traits have as yet been identified. The availability of the rat genome sequence and g enome-scale technologies, along with the ability to clone fertile adult rats, has substantially advanced the potential for functional genomics research in the rat model. The European Rat Tools for Functional Genomics (EURATools) consortium draws together leading European researchers in rat genetics, pharmacology, toxicology, disease pathophysiology, and genome biology and informatics. The central aim of this project is the development of integrated genome tools that will generate knowledge which can be translated into improvements in healthcare for highly prevalent diseases in the European Union. The EURATools aims will be achieved by integrating high-throughput sequencing and genotyping with informatics; by intensive analysis of phenotypes, gene seq uence and gene expression in congenic strains to identify genes and regulatory pathways for a wide range of rat disease phenotypes; and by establishment of optimised protocols for rat gene targeting. These new resources will significantly improve our und erstanding of complex genetic traits, and will enhance prospects for drug development and strategies for preventing and treating some of the commonest diseases in western societies.
Source :
cordis
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